NeoGen Plasma, Cosmelan and Dermamelan in London
Pigmentation Treatment in London
Sun spots, melasma and dark marks. Cleared, not covered.
Pigmentation has more than one cause, so we have more than one answer. NeoGen Plasma regenerates sun-damaged skin, evening tone while it smooths and firms, and the Cosmelan and Dermamelan methods by mesoestetic treat stubborn pigment and melasma at the source. We match the right one to your skin at a complimentary consultation.
- Nineteen years of expertise
- Three London clinics
- 250,000+ treatments performed
- Multi-award winning
Our Kensington clinic is regulated by the Care Quality Commission (ID 1‑129888578). View our registration
NeoGen Plasma: see it for yourself.
Sun damage, uneven tone, texture and the delicate eye area, treated together as the skin regenerates. Results keep building for up to 12 months after treatment.
Before and after images are shown for illustration. Individual results may vary.
Book my complimentary consultationWhat kind of pigmentation do you have?
Pigmentation is not one condition, it is several. Identifying yours correctly is the difference between fading it and clearing it. Choose the one that sounds most like you.
Choose what you see
Sun damage with texture and fine lines
Years of UV exposure rarely leave colour alone. Uneven tone tends to arrive with rougher texture, fine lines and a loss of firmness.
FDA-cleared nitrogen plasma regenerates the structure of the skin, so tone, texture and tightness improve together rather than one at a time. How NeoGen works
NeoGen Plasma is available at our Chelsea and St John’s Wood clinics.
Dark circles and crepey under-eye skin
Dark, tired-looking lids and thin, crepey skin around the eyes, where most treatments cannot go.
Nitrogen plasma can be used right up to the lash line, brightening and tightening dark, tired-looking lids. How NeoGen works
NeoGen Plasma is available at our Chelsea and St John’s Wood clinics.
Sun spots and age spots
Small dark patches on the face, hands and décolletage, caused by years of UV exposure triggering excess melanin.
The professional depigmenting method by mesoestetic that visibly reduces discolouration and helps keep it from returning. When spots come with texture, lines or laxity, NeoGen Plasma treats them together. How the method works
Melasma and hormonal pigmentation
Larger, irregular patches driven by hormones, pregnancy, contraception or sun. Often called the “pregnancy mask”.
Regulates the enzyme that produces melanin, treating stubborn pigment at its source rather than bleaching the surface. How the method works
Light and heat can make melasma worse, which is why we assess it in person before recommending anything.
Acne marks and dark marks after breakouts
Flat discolouration left behind after breakouts, injury or inflammation heals. Common in acne-prone skin.
Lifts the discolouration left behind by breakouts while renewing skin texture. Where there is scarring too, RF Microneedling or NeoGen Plasma work on the texture.
Intimate area darkening
Darker skin in the intimate area, groin and inner thighs, often from hormones, friction or hair removal.
A depigmentation protocol by mesoestetic developed specifically for the intimate area, carried out discreetly and with care. How the method works
Most women arrive with more than one type, and sometimes a combination gives the best result. Your complimentary consultation confirms the right match for your skin.
Find my match at a consultationNeoGen Plasma: regenerate, not just resurface
When sun damage brings uneven tone together with texture, fine lines or laxity, NeoGen goes deeper. Nitrogen plasma warms the whole structure of the skin without creating an open wound, so tone, texture and firmness improve together rather than one at a time.
Because the surface layer is left in place, it acts as a natural dressing while new skin forms underneath.
- Pigmentation, texture and firmness in one planSoftens sun-induced pigmentation while smoothing texture and tightening the skin.
- Right up to the lash lineCan be used on the delicate eye area, brightening and tightening dark, tired-looking lids.
- Results that keep buildingTightening can be seen after one session, and results keep improving for up to 12 months as new collagen forms.
- FDA clearedFor seven skin indications, as stated by the manufacturer. Individual results vary.
Usually 3 to 5 lighter sessions around four weeks apart, with mild redness for a day or two.
A single high energy session. The treated skin darkens and sheds over 5 to 7 days as new skin comes through.
Cosmelan and Dermamelan by mesoestetic
Described by mesoestetic as the world’s leading professional depigmentation method. Rather than bleaching the surface, it regulates melanin production at its source. In mesoestetic’s reported data the method reduces pigmentation in around 95% of cases, with around 80% improvement visible after the first month. Manufacturer reported figures. Individual results vary.
- 01
The in-clinic mask
Your practitioner applies the professional depigmenting mask, which you wear for 8 to 12 hours depending on your skin type.
- 02
The renewal phase
Over 5 to 7 days your skin gently peels, lifting away built-up pigment to reveal fresher, more even-toned skin beneath.
- 03
Protect and maintain
A simple home maintenance cream and daily SPF50+ keep melanin regulated, so the pigment stays away.
For sun spots, mild to moderate pigmentation and first-time depigmentation treatments. The usual starting point.
The more intensive option, for stubborn, moderate to severe pigmentation and persistent melasma.
Developed specifically for the intimate area, groin and inner thighs, where hormones, friction and hair removal often leave the skin darker.
- In clinic
- Up to 1 hourFor the application, then the mask stays on at home.
- Sessions
- OnePlus a simple home care routine.
- Back to work
- Around 3 daysPeeling settles within 7 to 10 days.
- Results
- From 2 weeksAt their best by 1 to 2 months.
Before
After
Before
After Working to the manufacturer’s own protocols
Our sister brand EF SKIN is an official UK distributor of mesoestetic, the maker of Cosmelan and Dermamelan, so our practitioners are trained and supported directly on the methods they deliver.
NeoGen Plasma, Cosmelan or Dermamelan?
How the three compare on what they treat, how long they take and how much downtime to plan for. Your practitioner confirms the right one for your skin.
| NeoGen PlasmaPlasma regeneration | CosmelanDepigmentation method | DermamelanDepigmentation method | |
|---|---|---|---|
| Best for | Sun damage that comes with texture, fine lines or laxity, and dark, tired-looking eyes | Mild to moderate sun spots and first-time depigmentation | Stubborn melasma and deep, persistent pigmentation |
| How it works | Nitrogen plasma warms the whole structure of the skin without an open wound, so tone, texture and firmness improve together | An in-clinic depigmenting mask, then a home routine that keeps melanin regulated | The more intensive depigmenting mask, then a home phase your practitioner tailors to you |
| Your course | A single high energy session, or 3 to 5 lighter sessions around four weeks apart | One session, plus simple home care | One session, plus a home phase |
| In clinic | 10 to 60 minutes | Up to 1 hour | Up to 1 hour |
| Downtime | From a day or two of redness to 5 to 7 days, set to suit your diary | Back to work in around 3 days. Peeling settles within 7 to 10 days | Back to work in around 3 days. Peeling is more pronounced and settles within 7 to 10 days |
| Results | Tightening after one session, building for up to 12 months | From 2 weeks, at their best by 1 to 2 months | From 2 weeks, at their best by 1 to 2 months |
| Areas | Face, eyes, neck, chest and hands | Face. Other areas assessed at consultation | Face, plus the intimate area, groin and inner thighs with Dermamelan Intimate |
| Where | Chelsea and St John’s Wood | All three clinics | All three clinics |
We also offer chemical peels for brightening and maintenance, RF Microneedling where acne marks come with scarring, and laser resurfacing for sun damage alongside texture change. Courses, timings and downtime are typical ranges and vary from person to person.
Is pigmentation treatment right for me?
Your consultation includes a full medical history and an assessment of your skin, and we only go ahead if treatment is safe and right for you. If a different approach would serve you better, you will be told honestly.
Not sure which treatment suits your concern? Try our Treatment Guide.
It’s often a good fit if
- You have sun spots, melasma, acne marks or uneven tone you’d like cleared, not covered
- Your pigmentation comes with texture, fine lines or crepey eyes, which NeoGen Plasma treats together
- You’d like a method designed for all skin phototypes: Cosmelan and Dermamelan are made to be used across them
- You’re happy to follow a simple home routine and wear SPF50+ every day
Talk to us first if
- Your pigmentation is hormonal. It can return with new triggers, so we plan maintenance with you
- You’re considering light or laser treatment for melasma, where light and heat can make pigmentation worse
- You have a medical condition or take any medication. Tell us at your consultation, where we take your full medical history
Every plan is tailored to you, and results vary from person to person.
From consultation to clearer skin
Pigmentation is complex. Results come from expert diagnosis, not just technology. Here is what to expect.
Your complimentary consultation
We assess your skin, identify your pigmentation type, whether melasma, sun damage or post-inflammatory, and take your full medical history. There’s no obligation to go ahead.
Your bespoke plan
Your treatment, or combination of treatments, is matched to your pigmentation, skin tone and lifestyle, including how much downtime suits you.
Your treatment
NeoGen Plasma takes 10 to 60 minutes in clinic. For Cosmelan or Dermamelan, your practitioner applies the depigmenting mask, which you wear for 8 to 12 hours depending on your skin type.
Renewal
After Cosmelan or Dermamelan your skin gently peels over 5 to 7 days. After NeoGen, expect anything from a day or two of redness to 5 to 7 days as the treated skin sheds, depending on the energy chosen.
Protect and maintain
A simple home care routine and daily SPF50+ lock in your results and help keep pigment from returning. We guide you through both and plan maintenance with you.
Book your complimentary pigmentation consultation
Tell us a little about you and a member of our team will be in touch within 24 hours to answer your questions and find a time that suits you.
Request your consultation
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Your consultation request has been received. A member of our team will be in touch within 24 hours.
- Complimentary, with no obligation to go ahead
- A reply within 24 hours from a member of our team
- Your pigmentation type identified before anything is recommended
Prefer to choose your own time?
See available times at your nearest clinic and book online straight away.
See the calendar and book onlinePrefer to call? Our three clinics:
- Kensington020 7937 5554
- Chelsea020 7368 7676
- St John’s Wood020 7449 0888
Complimentary consultations exclude medical and doctor appointments, which may incur a fee.
How much does pigmentation treatment cost?
Every plan is personal to your pigmentation type, the method chosen and any treatments we combine, so we talk you through your options and your investment at your complimentary consultation rather than online. There is no obligation to go ahead.
What do our patients say?
Reviews left on Google by patients at our Kensington, Chelsea and St John’s Wood clinics.
4.5
Average rating on Google across our three London clinics.
★★★★★“Yana is the best! Super thorough and gives the best results. Does not rush treatments, takes time and care to give the best possible treatment and is friendly and welcoming. Would keep coming just for Yana!”
★★★★★“Faten is exceptionally professional and meticulous. She personalizes each treatment, delivering impressive results. Highly recommended!”
★★★★★“Wonderful team. A special thanks to the wonderful Lara who was very attentive toward me and went out of her way to accommodate me.”
Your questions, answered
Can’t see your question? Our patient team is happy to help on 0207 361 1000.
What is the best treatment for pigmentation?
It depends on your pigmentation type and how deep it sits. NeoGen Plasma is ideal when sun damage comes with texture, fine lines or laxity, including around the eyes. Cosmelan suits mild to moderate pigmentation and sun spots, Dermamelan is the more intensive option for stubborn cases and melasma, and Dermamelan Intimate is the route for darkening in the intimate area. Your complimentary consultation confirms the right match, and sometimes a combination gives the best result.
Does NeoGen Plasma treat pigmentation?
Yes. NeoGen Plasma softens sun-induced pigmentation while it smooths texture and tightens the skin. Nitrogen plasma warms the whole structure of the skin without creating an open wound, so tone, texture and firmness improve together. Results keep building for up to 12 months as new collagen forms.
Can you treat dark circles under the eyes?
Yes. NeoGen Plasma can be used right up to the lash line, brightening and tightening dark, tired-looking lids and crepey under-eye skin.
Does it work for melasma?
Melasma is one of the concerns the Dermamelan method was designed for. It works by regulating the enzyme responsible for melanin production, treating melasma at its source rather than just the surface, and the home maintenance phase helps keep it from returning. In mesoestetic’s reported data the method reduces pigmentation in around 95% of cases, with visible improvement in the first month. Individual results vary, which is why we assess your melasma in person first.
What is the difference between Cosmelan and Dermamelan?
Both are depigmentation methods by mesoestetic that regulate melanin production at its source. Cosmelan is for mild to moderate pigmentation, sun spots and first-time depigmentation treatments. Dermamelan is the more intensive option, for stubborn, moderate to severe pigmentation and persistent melasma, and it is also available as Dermamelan Intimate for the intimate area.
How does the Cosmelan and Dermamelan treatment work?
Your practitioner applies a professional depigmenting mask in clinic, which you wear for 8 to 12 hours depending on your skin type. Over the next 5 to 7 days your skin gently peels, lifting away built-up pigment. A simple home maintenance cream and daily SPF50+ then keep melanin regulated so the pigment stays away.
What is the downtime?
Cosmelan and Dermamelan involve 5 to 7 days of gentle peeling, and most clients are back at work in around 3 days with the right home care. NeoGen Plasma is tailored to you: a gentle course brings a day or two of mild redness, while a single high energy treatment means 5 to 7 days as the treated skin darkens and sheds.
When will I see results?
With Cosmelan and Dermamelan, results show from around 2 weeks and are at their best by 1 to 2 months. With NeoGen Plasma, tightening can be seen after one session and results keep building for up to 12 months. Individual results vary.
Is it suitable for darker skin tones?
Cosmelan and Dermamelan are designed by mesoestetic to be used across all skin phototypes, which is one reason they are so widely used for melasma and post-inflammatory pigmentation. Your practitioner assesses your skin at consultation and confirms the safest, most effective option for your tone, including whether a light or energy-based treatment is appropriate for you.
Can you treat darkening in the intimate area?
Yes. Dermamelan Intimate is a depigmentation protocol by mesoestetic developed specifically for the intimate area, groin and inner thighs, where hormones, friction and hair removal often leave the skin darker. It follows the same principle as Dermamelan for the face: an in-clinic treatment followed by a simple home routine, carried out discreetly and with care. We talk it through with you privately at your complimentary consultation.
Can acne marks be treated?
Yes. Cosmelan or Dermamelan lift the discolouration left behind by breakouts while renewing skin texture. Where acne has also left scarring, RF Microneedling or NeoGen Plasma work on the texture, and the two approaches can be combined.
Will my pigmentation come back?
The depigmentation method does not just remove existing pigment, it regulates melanin production to help prevent it reappearing. Your home maintenance phase and daily SPF50+ are the keys to keeping results long term, and we guide you through both. Hormonal pigmentation can return with new triggers, so we plan maintenance with you.
Is IPL or laser good for melasma?
Not usually. Light and heat can make melasma worse, which is why we assess your pigmentation in person and often recommend Dermamelan, which regulates pigment at its source.
How much does pigmentation treatment cost?
Every plan is personal to your pigmentation type, the method chosen and any treatments we combine, so we talk you through your options and your investment at your complimentary consultation rather than online. There is no obligation to go ahead.
Which EF MEDISPA clinics offer pigmentation treatment?
Cosmelan and Dermamelan are available at all three of our clinics: Kensington on Kensington Church Street, Chelsea on the Kings Road and St John’s Wood on St John’s Wood High Street. NeoGen Plasma is available at Chelsea and St John’s Wood.
Where can I have pigmentation treatment in London?
Cosmelan and Dermamelan are available at all three of our clinics, and NeoGen Plasma at Chelsea and St John’s Wood. Call or WhatsApp your nearest one.
Kensington
- Address
- 29 Kensington Church Street, London W8 4LL
- Treatments
- Cosmelan, Dermamelan
- Stations
- High Street Kensington, Olympia
- Open
- Tuesday and Wednesday 9am to 6pm, Thursday 11am to 8pm, Friday 10am to 7pm, Saturday 10am to 6pm. Closed Sunday and Monday.
Chelsea
- Address
- 193 Kings Road, London SW3 5ED
- Treatments
- NeoGen Plasma, Cosmelan, Dermamelan
- Stations
- Sloane Square, South Kensington
- Open
- Monday to Friday 9am to 8pm, Saturday 9am to 7pm. Closed Sunday.
St John’s Wood
- Address
- 69 St John’s Wood High Street, London NW8 7NL
- Treatments
- NeoGen Plasma, Cosmelan, Dermamelan
- Station
- St John’s Wood
- Open
- Tuesday and Wednesday 9am to 6pm, Thursday and Friday 10am to 7pm, Saturday 10am to 6pm. Closed Sunday and Monday.
You might also like to explore
- NeoGen PlasmaNitrogen plasma skin regeneration for hooded eyes, lines, texture, sun damage and acne scarring.
- RF MicroneedlingMicroneedles and radiofrequency heat to smooth lines, pores and acne scars, and tighten the skin beneath.
- Facials and PeelsBrightening facials and chemical peels, lovely for maintenance after a depigmentation treatment.
This page was last updated in October 2026.






